Compparing best practices one can see, that the golden way is just to have super powers, as Alice given by the T-Virus. For the case one is not able to generate superpowers it can be a problem, dealing with attacking Zombies.
"Dawn of the Dead" shows, that leaving a safe house is in most cases a bad idea. There are just a few reports on survivors reaching actually a camp when leaving their hide out. In Fact the best succes rate is provided when one just stays at home, and waits for help. Very uncommon informations are provided from "Rave to the grave", this movie throws up the question if staying at home causes the risk, to be bombed by the government.